Fisher C G, Blachut P A, Salvian A J, Meek R N, O'Brien P J
Department of Orthopaedics, University of British Columbia, Vancouver, Canada.
J Orthop Trauma. 1995 Feb;9(1):1-7. doi: 10.1097/00005131-199502000-00001.
A prospective, randomized clinical trial in 304 orthopaedic trauma patients with hip and pelvic fractures was conducted to investigated the effectiveness of pneumatic sequential leg compression devices (PSLCDs) for the prevention of thromboembolic disease. The control group received no specific form of prophylaxis. Patients were followed by venous Doppler, duplex can, and ventilation perfusion lung scans. The study end-point was documented pulmonary embolism and/or deep vein thrombosis. The incidence of a venous thromboembolic event in the control group was 11% and in the experimental group 4%. This difference was statistically significant (p = 0.02). These patients were also stratified into hip and pelvic fracture groups. In the hip fracture patients, the control group had a thromboembolic event incidence of 12% and the experimental group 4%. This difference was also statistically significant (p = 0.03). In the pelvic fracture group there was a thromboembolic incidence of 11% in the controls, demonstrating this patient population to be at significant risk. In this group, the PSLCDs were not statistically shown to be effective. Pneumatic leg compression devices are effective in reducing the incidence of thromboembolic events in patients with hip fractures.
对304例髋部和骨盆骨折的骨科创伤患者进行了一项前瞻性随机临床试验，以研究气动序贯腿部压迫装置（PSLCDs）预防血栓栓塞性疾病的有效性。对照组未接受任何特定形式的预防措施。通过静脉多普勒、双功超声检查和通气灌注肺扫描对患者进行随访。研究终点为记录的肺栓塞和/或深静脉血栓形成。对照组静脉血栓栓塞事件的发生率为11%，实验组为4%。这一差异具有统计学意义（p = 0.02）。这些患者还被分为髋部骨折组和骨盆骨折组。在髋部骨折患者中，对照组血栓栓塞事件的发生率为12%，实验组为4%。这一差异也具有统计学意义（p = 0.03）。在骨盆骨折组中，对照组的血栓栓塞发生率为11%，表明该患者群体存在显著风险。在该组中，PSLCDs在统计学上未显示有效。气动腿部压迫装置可有效降低髋部骨折患者血栓栓塞事件的发生率。
