Chemical incompatibility between procainamide hydrochloride and glucose following intravenous admixture.
作者信息
Sianipar A, Parkin J E, Sunderland V B
机构信息
School of Pharmacy, Curtin University of Technology, Perth, Australia.
出版信息
J Pharm Pharmacol. 1994 Dec;46(12):951-5. doi: 10.1111/j.2042-7158.1994.tb03249.x.
Abstract
The chemical reaction between procainamide hydrochloride and glucose following admixture to glucose infusion has been investigated. Substantial amounts (10-15% after 10 h at room temperature) of the procainamide is lost with the formation of a mixture of the corresponding alpha- and beta-glucosylamines. The chemical identity of the latter compounds was confirmed by 13C and 1H nuclear magnetic resonance spectroscopy.
摘要
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