Mitsuhashi S, Nagasawa T, Kamoshita M, Otani K, Hasegawa Y, Kojima H, Ninomiya H, Nakazawa M, Abe T
Division of Hematology, University of Tsukuba.
Rinsho Ketsueki. 1995 Feb;36(2):115-20.
Sixty-seven years-old female, who was an atomic bomb survivor in Hiroshima, was pointed out as having leukopenia and anemia in 1991. She was referred to Tsukuba University Hospital in June 1992. Her peripheral blood count showed pancytopenia- 2,600/microliters WBC, 10.5 g/dl hemoglobin, and 80,000/microliters platelets- at that time. BM biopsy revealed hypoplastic marrow and increased peroxidase-negative blasts (32.8%). Surface marker analysis of the blasts showed a feature of CD2+ CD33+ CD34+ CD13+ CD3-. Electronmicroscopically, myeloperoxidase was positive. She was diagnosed as having hypoplastic leukemia of which the blasts had a feature of AML-M0 by FAB-group. After 6 months' silent period, her pancytopenia became profound. We successfully reduced the blasts by BAM therapy. However, she died of bacterial pneumonia during the myelosuppressive state. This is a case of minimally differentiated hypoplastic AML.
一名67岁女性，是广岛原子弹爆炸幸存者，1991年被发现患有白细胞减少症和贫血。1992年6月她被转诊至筑波大学医院。当时她的外周血细胞计数显示全血细胞减少——白细胞2600/微升、血红蛋白10.5克/分升、血小板80000/微升。骨髓活检显示骨髓增生低下，过氧化物酶阴性原始细胞增多（32.8%）。原始细胞的表面标志物分析显示具有CD2+ CD33+ CD34+ CD13+ CD3-的特征。电镜检查显示髓过氧化物酶阳性。她被诊断为增生低下性白血病，其原始细胞具有FAB分型中AML-M0的特征。经过6个月的静止期后，她的全血细胞减少变得严重。我们通过BAM疗法成功减少了原始细胞。然而，她在骨髓抑制状态期间死于细菌性肺炎。这是一例低分化增生低下性急性髓细胞白血病病例。
