Masuoka H, Kobayashi M, Kaito K, Yoshida M, Sekita T, Saeki A, Nishiwaki K, Shimada T, Ochiai S, Ootsubo H
Second department of Internal Medicine, Jikei University School of Medicine.
Rinsho Ketsueki. 1995 Feb;36(2):156-8.
Bilateral ankle skin ulcers developed in a 61-year-old man in the chronic phase of chronic myelogenous leukemia receiving hydroxyurea therapy. The circulating immune complex (anti-C3d antibody) was high in this case, but vasculitis was not observed in the pathological findings of biopsied skin materials. This association has been reported in patients who had chronic myelogenous leukemia or other myeloproliferative disorders and were treated with hydroxyurea. It is likely that skin ulcers are caused by hydroxyurea.
