Li H, Godfrey D A, Rubin A M
Department of Otolaryngology, Head and Neck Surgery, Medical College of Ohio, Toledo 43699, USA.
Laryngoscope. 1995 Apr;105(4 Pt 1):417-24. doi: 10.1288/00005537-199504000-00015.
Unilateral removal of Scarpa's ganglion and neurectomy of the peripheral vestibular nerve branches were compared in rats as methods to eliminate primary vestibular input. Ocular nystagmus was consistently observed after both types of lesion, but it completely disappeared within 4 to 7 days. Imbalance and rotation were more serious and prolonged after ganglionectomy than after peripheral neurectomy. Corresponding with these differences in symptoms were differences in terminal degeneration. After ganglionectomy, degenerated axons and terminals were distributed throughout all terminal regions of primary vestibular fibers on the lesioned side, while after peripheral neurectomy, the degeneration was more limited. The results of this study suggest that vestibular ganglionectomy is a more successful approach than peripheral vestibular neurectomy for removing the primary vestibular input.
在大鼠中比较了切除斯卡帕神经节和切断外周前庭神经分支这两种消除初级前庭输入的方法。两种损伤后均持续观察到眼球震颤，但在4至7天内完全消失。与外周神经切断术相比，神经节切除术后的失衡和旋转更严重且持续时间更长。症状的这些差异与终末变性的差异相对应。神经节切除术后，变性的轴突和终末分布在损伤侧初级前庭纤维的所有终末区域，而外周神经切断术后，变性则更局限。本研究结果表明，对于去除初级前庭输入，前庭神经节切除术比外周前庭神经切断术更成功。
