Korn E, Van Hoff J, Buckley P, Daughaday W H, Carpenter T O
Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520-8064, USA.
Med Pediatr Oncol. 1995 Jun;24(6):392-6. doi: 10.1002/mpo.2950240610.
A 5-year-old boy with an abdominal mass was found to have a primary renal tumor of poorly identifiable histology. Prior to resection of the tumor, the patient exhibited several episodes of biochemical hypoglycemia. The hypoglycemia did not recur after operation. Analysis of tumor tissue and of pre- and post-operative sera by column chromatography showed elevated insulin-like growth factor II (IGF-II) levels in the tumor; an abnormal large-molecular weight precursor form of IGF-II (pro-IGF-II) comprised 53% of total IGF-II in the tumor and 42% in preoperative serum. No pro-IGF-II was found in the serum 6 weeks post-operatively. Abnormal IGF-II secreted by the tumor may have mediated the hypoglycemia seen prior to tumor resection. This pediatric renal tumor is the first to our knowledge for which an association of non-islet cell tumor-related hypoglycemia and elevated tumor IGF-II content has been described.
一名患有腹部肿块的5岁男孩被发现患有组织学难以明确的原发性肾肿瘤。在肿瘤切除术前，患者出现了几次生化性低血糖发作。术后低血糖未再复发。通过柱色谱法对肿瘤组织以及术前和术后血清进行分析，结果显示肿瘤中胰岛素样生长因子II（IGF-II）水平升高；一种异常的大分子前体形式的IGF-II（pro-IGF-II）在肿瘤中的IGF-II总量中占53%，在术前血清中占42%。术后6周血清中未发现pro-IGF-II。肿瘤分泌的异常IGF-II可能介导了肿瘤切除术前出现的低血糖。据我们所知，这种小儿肾肿瘤是首例被描述为与非胰岛细胞瘤相关低血糖和肿瘤IGF-II含量升高有关的病例。
