Harmouch A, Guerrero J M, Osuna C
Department of Medical Biochemistry and Molecular Biology, University of Seville School of Medicine, Spain.
Neurosci Lett. 1994 Dec 5;182(2):303-5. doi: 10.1016/0304-3940(94)90822-2.
Herein, we investigate the mechanisms involved in the adrenergically mediated stimulation of rat pineal N-acetyltransferase (NAT) activity during development using an in vitro model. Compared with adults, results suggest a different regulation of pineal NAT activity in growing rats where a similar efficiency of alpha- and beta-adrenergic receptor agonists is observed during the 1st weeks of age for activating the enzyme. In adult rats, beta- but not alpha-adrenergic receptors appear to play the preeminent role. The results indicate that the adrenergic receptor agonists used acted in a non-specific manner by binding to relatively immature receptors early during development.
在此，我们使用体外模型研究了发育过程中肾上腺素介导的大鼠松果体N-乙酰转移酶（NAT）活性刺激所涉及的机制。与成年大鼠相比，结果表明，在幼鼠中松果体NAT活性的调节方式不同，在出生后的第一周，α-和β-肾上腺素能受体激动剂激活该酶的效率相似。在成年大鼠中，似乎是β-而不是α-肾上腺素能受体起主要作用。结果表明，所使用的肾上腺素能受体激动剂通过在发育早期与相对不成熟的受体结合而以非特异性方式起作用。
