99锝-消旋-六甲基丙二胺肟标记白细胞闪烁扫描术在检测血管移植物感染中的诊断价值

Diagnostic value of 99Tcm-d,l-HMPAO-labelled leukocyte scintigraphy in the detection of vascular graft infections.

作者信息

Krznaric E, Nevelsteen A, van Hoe L, de Roo M, Schiepers C, Verbruggen A, Mortelmans L

机构信息

Department of Nuclear Medicine, Katholieke Universiteit, Leuven, Belgium.

出版信息

Nucl Med Commun. 1994 Dec;15(12):953-60. doi: 10.1097/00006231-199412000-00006.

DOI:10.1097/00006231-199412000-00006

PMID:7715894

Abstract

Prosthetic vascular graft infection is a relatively uncommon complication of peripheral vascular surgery. We retrospectively analysed technetium-99m-d,l-hexamethylpropylene amine oxime (99Tcm-d,l-HMPAO) labelled leukocyte scans of 21 patients with a suspected vascular graft infection. Operative findings, bacteriological cultures, radiological findings or clinical follow-up were used to confirm the diagnosis. We found eight true-positive and six true-negative cases. There were no false-positive scintigraphic diagnoses. The false-negative rate was 33% (n = 7). Our results show a sensitivity of 53%, a specificity of 100% and an accuracy of 66%. The conclusion is that a negative 99Tcm-d,l-HMPAO-labelled leukocyte scan is of limited value in ruling out a vascular graft infection. A combination of computed tomography (CT-scan) and a 99Tcm-d,l-HMPAO-labelled leukocyte scan is probably the most efficient way of diagnosing a vascular graft infection.

摘要

人工血管移植物感染是周围血管手术相对少见的并发症。我们回顾性分析了21例疑似血管移植物感染患者的锝-99m - d，l-六甲基丙烯胺肟（99Tcm - d，l-HMPAO）标记白细胞扫描结果。通过手术所见、细菌培养、影像学检查结果或临床随访来确诊。我们发现8例假阳性和6例假阴性病例。没有假阳性的闪烁显像诊断。假阴性率为33%（n = 7）。我们的结果显示敏感性为53%，特异性为100%，准确性为66%。结论是，99Tcm - d，l-HMPAO标记白细胞扫描结果为阴性在排除血管移植物感染方面价值有限。计算机断层扫描（CT扫描）和99Tcm - d，l-HMPAO标记白细胞扫描相结合可能是诊断血管移植物感染最有效的方法。