De Albertis P, Oliveri M, Quadri P, Serafini G, Cavallo A, Orlando O, Perona F, Barile A, Gandolfo N, Veirana M
Servizio di Radiologia Diagnostica, Ospedale S. Paolo, Savona.
Radiol Med. 1995 Jan-Feb;89(1-2):28-35.
The authors tried to identify useful flowmetric values and color-Doppler patterns for the differential diagnosis between benign and malignant solid breast lesions. To this purpose, 106 patients with breast nodules detected at mammography and/or high resolution US were examined. A US scanner with a linear 7.5 MHz transducer, a narrow sample volume, a PRF ranging (650-800 Hz) and a wall filter value of 50 Hz were used. Three parameters were considered: the number vascular sites, systolic peak velocity and pulsatility index. All these parameters related to tumor volume. Several (> 2) vascular sites, high peak velocity and quite high pulsatility index were demonstrated in malignant tumors (46 lesions). Among benign tumors no vascular site was identified in 32 of 60 lesions and no more than 2 sites were identified in 26 of 60 lesions, except for 2 phylloides tumors. Sensitivity, specificity, positive and negative predictive values and overall accuracy rates were, as for the "vascular sites" parameter, 78%, 96%, 94%, 85%, 88%, respectively; as regards the "peak systolic velocity" 81%, 86%, 89%, 75%, 83% respectively; as regards the "pulsatility index" 100%, 85%, 100%, 85%, 94% respectively.
作者试图确定有助于鉴别乳腺实性良恶性病变的血流动力学参数值及彩色多普勒血流图表现。为此，对106例经乳腺钼靶摄影和/或高分辨率超声检查发现乳腺结节的患者进行了检查。使用配备7.5MHz线性探头的超声扫描仪，取样容积窄，脉冲重复频率（PRF）范围为650 - 800Hz，壁滤波器值为50Hz。研究考虑了三个参数：血管点数量、收缩期峰值流速和搏动指数。所有这些参数均与肿瘤体积相关。在46个恶性肿瘤中表现为多个（>2个）血管点、高峰值流速和较高的搏动指数。在60个良性肿瘤中，60个病变中的32个未发现血管点，60个病变中的26个（除2例叶状肿瘤外）发现不超过2个血管点。就“血管点”参数而言，敏感度、特异度、阳性预测值、阴性预测值及总体准确率分别为78%、96%、94%、85%、88%；就“收缩期峰值流速”而言，分别为81%、86%、89%、75%、83%；就“搏动指数”而言，分别为100%、85%、100%、85%、94%。
