Mühlberger N, Kraft W
I. Medizinischen Tierklinik, Ludwig-Maximilians-Universität München.
Tierarztl Prax. 1994 Dec;22(6):567-73.
Overproportional GLDH-increase was found to be the most frequently appearing pathological enzyme pattern in canine practice. Thus it could be shown that GLDH deviates, in spite of its mitochondrial localization and greater molecular weight, more frequently and to a higher degree from its reference value than the parameters ALT, AST, AP, GGT and Bilirubin. The results of the study suggest that the liberation of the enzyme is less determined by the intensity than by the intralobular target of the liver insult. Therefore an increase in GLDH-activity should no longer be interpreted as the result of severe liver damage. On the contrary, the enzyme appeared to be the most sensitive indicator for the diagnosis of primary and secondary hepatopathies. The phenomenon of isolated GLDH-increase could be interpreted in almost every disease group as an appearance of the over-proportional increase and can therefore be understood as a serological expression of a slight, perivenous liver affection. Only with effusion patients the enzyme pattern should be regarded as an independent finding, because it has extrahepatic reasons. The induction of the enzyme in cases of diabetes mellitus is discussed.
在犬类临床实践中，发现谷胱甘肽脱氢酶（GLDH）过度升高是最常见的病理酶学模式。因此可以表明，尽管GLDH定位于线粒体且分子量较大，但与丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、碱性磷酸酶（AP）、γ-谷氨酰转移酶（GGT）和胆红素等参数相比，它更频繁且程度更高地偏离其参考值。研究结果表明，酶的释放与其说是由肝脏损伤的强度决定，不如说是由小叶内损伤靶点决定。因此，GLDH活性升高不应再被解释为严重肝损伤的结果。相反，该酶似乎是诊断原发性和继发性肝病最敏感的指标。在几乎每个疾病组中，孤立的GLDH升高现象都可被解释为过度升高的表现，因此可被理解为轻度肝静脉周围病变的血清学表现。只有在积液患者中，酶学模式应被视为独立的发现，因为其有肝外原因。文中还讨论了糖尿病病例中该酶的诱导情况。
