Kreze A, Spirová E, Putz Z, Danko J, Visnovský J, Breza J, Pauer M, Renker B
Endokrinologický ústav, L'ubochna.
Vnitr Lek. 1995 Jan;41(1):56-60.
Active Cushing's syndrome during pregnancy is a rare phenomenon which was so far described in the literature only in 85 women. The authors give an account of a patient who developed Cushing's syndrome during pregnancy and who was delivered during the eighth month of a healthy foetus by caesarean section, afterwards the hypercortisolism associated with hyperaldosteronism was treated by dextrolateral adrenalectomy. In the removed adrenal gland was a cortical adenoma made up of clear cells and cells reminding of the zona glomerulosa. Subsequently the authors summarize data from the literature on the prevalence of different pathogenetic forms of Cushing's syndrome in pregnant women, on the influence of hypercortisolism on mother and foetus, on the optimal diagnosis and therapy of this syndrome during pregnancy.
妊娠期活动性库欣综合征是一种罕见现象，迄今为止文献中仅报道过85例女性患者。作者报告了一名在孕期发生库欣综合征的患者，该患者在孕8个月时通过剖宫产分娩出一个健康胎儿，随后通过右侧肾上腺切除术治疗了与醛固酮增多症相关的皮质醇增多症。切除的肾上腺中有一个由透明细胞和类似球状带的细胞组成的皮质腺瘤。随后，作者总结了文献中关于孕妇库欣综合征不同致病形式的患病率、高皮质醇血症对母亲和胎儿的影响以及孕期该综合征的最佳诊断和治疗的数据。
