Lehmann Z, Wierzchowiecki M, Michalski M, Stasiński T, Ozegowski S
II Kliniki Kardiologii Instytutu Kardiologii Ak. Med. im. K. Marcinkowskiego, Poznaniu.
Wiad Lek. 1994 Aug;47(15-16):574-8.
In 42 patients aged 33 to 79 years (mean age 55 years) with NYHA grade II chronic congestive circulatory failure, a comparative assessment was carried out of the effectiveness of treatment with captopril (29 patients, daily dose 18.75-150 mg, mean 82.5 mg) adn digoxin (13 patients, daily dose 0.125-0.5 mg, mean 0.275 mg). The patients were administered the drugs, depending on the improvement obtained, for 3-5 weeks. In the assessment of the effectiveness of the treatment, the following was taken into account: medical examination, laboratory investigations, chest X-ray, exercise tests and haemodynamic parameters measured during 2D and M echocardiographic examination. In the group of patients treated with digoxin the following was observed: a significant, in comparison to the patients receiving captopril, reduction of the heart rate by 11 beats per minute, decrease of the heart volume index by 50 ml/m2 and increase of the stroke volume by 14 ml. Higher effectiveness of captopril was observed as increase of the maximal workload during exercise test by 21 W and prolongation of its duration by three minutes. It seems that captopril may find use also in the treatment of early stages of circulatory failure.
对42例年龄在33至79岁（平均年龄55岁）、纽约心脏协会（NYHA）心功能分级为II级的慢性充血性循环衰竭患者，进行了卡托普利（29例患者，日剂量18.75 - 150毫克，平均82.5毫克）和地高辛（13例患者，日剂量0.125 - 0.5毫克，平均0.275毫克）治疗效果的对比评估。根据病情改善情况，给予患者药物治疗3至5周。在评估治疗效果时，考虑了以下因素：体格检查、实验室检查、胸部X光、运动试验以及二维和M型超声心动图检查期间测量的血流动力学参数。在接受地高辛治疗的患者组中观察到：与接受卡托普利治疗的患者相比，心率显著降低11次/分钟，心脏容积指数降低50毫升/平方米，每搏输出量增加14毫升。观察到卡托普利的疗效更高，运动试验中的最大工作量增加21瓦，持续时间延长三分钟。卡托普利似乎也可用于循环衰竭早期阶段的治疗。
