Stiel G M, Reblin T, Bührlen M, Lattermann A, Nienaber C A
Universitätskrankenhaus Eppendorf, Abt. für Kardiologie, Hamburg.
Z Kardiol. 1995 Feb;84(2):86-91.
Lipoprotein (a) (Lp(a)) levels are genetically determined and levels higher than 25 mg/dl are associated with increased prevalence of coronary artery disease (CAD). We studied gender differences in 76 men and 20 women undergoing coronary artery bypass graft surgery (CABG) for a potential association between Lp(a) levels both in serum and the aortic wall (Apo(a)) and the severity of CAD determined by an atherosclerosis score (CS) using quantitative coronary angiography (QCA). Serum Lp(a) and tissue Apo(a) do not correlate with the severity of CAD as assessed from QCA (r = 0.09 and r = 0.14, resp.). 60% of women but only 39% of men had serum Lp(a) levels higher than 25 mg/dl. Women were 8 years older (65 +/- 8 vs. 57 +/- 8 years, p < 0.001) and had 1.5 times higher mean serum Lp(a) and 1.75 times higher mean tissue Apo(a) levels (47 +/- 41 vs. 32 +/- 40 mg/dl and 33 +/- 34 vs. 19 +/- 24 micrograms/g WW, p < 0.05) than men with identical CS (35 +/- 8 vs. 33 +/- 8, p = NS). The serum levels of cholesterol, triglycerides, and high-density lipoprotein were similar in the two groups. There is no association between Lp(a) and Apo(a) and the severity of coronary atherosclerosis in men and women undergoing coronary artery bypass surgery.
脂蛋白(a) [Lp(a)] 水平由基因决定，高于25mg/dl的水平与冠状动脉疾病（CAD）患病率增加相关。我们研究了76名男性和20名女性在接受冠状动脉搭桥手术（CABG）时的性别差异，以探讨血清和主动脉壁中Lp(a)水平 [载脂蛋白(a)（Apo(a)）] 与通过定量冠状动脉造影（QCA）测定的动脉粥样硬化评分（CS）所确定的CAD严重程度之间的潜在关联。血清Lp(a)和组织Apo(a)与QCA评估的CAD严重程度不相关（分别为r = 0.09和r = 0.14）。60%的女性血清Lp(a)水平高于25mg/dl，而男性仅为39%。女性年龄大8岁（65±8岁对57±8岁，p < 0.001），在相同CS（35±8对33±8，p = 无显著性差异）的情况下，其平均血清Lp(a)水平高1.5倍，平均组织Apo(a)水平高1.75倍（47±41对32±40mg/dl和33±34对19±24μg/g湿重，p < 0.05）与男性相比。两组的胆固醇、甘油三酯和高密度脂蛋白血清水平相似。在接受冠状动脉搭桥手术的男性和女性中，Lp(a)和Apo(a)与冠状动脉粥样硬化严重程度之间无关联。
