氧氟沙星经三种给药途径的药代动力学。 （注：原英文表述中多了一个of，正确表述应该是Pharmacokinetics of ofloxacin through three administration routes. 翻译为“氧氟沙星经三种给药途径的药代动力学” ）
Pharmacokinetics of ofloxacin through three administration routes.
作者信息
Zhuo H T, Lu J Z, Xia X R, Ling S S
机构信息
Department of Clinical Pharmacology, Jinling Hospital, Nanjing, China.
出版信息
Zhongguo Yao Li Xue Bao. 1994 Sep;15(5):411-3.
This paper reports the pharmacokinetic characteristics of ofloxacin (Ofl) through 3 administration routes in 42 patients with respiratory tract infections. The concentration-time data were fitted with a two-compartment model for infusion (inf) and im, and a one-compartment model for po. The pharmacokinetic parameters of Ofl through inf, im and po were: T1/2 beta or T1/2K 6.0 +/- 1.3, 5.0 +/- 1.0, and 5.0 +/- 0.7 h; Vc or Vd 58 +/- 16, 68 +/- 27 and 94 +/- 25 L; Cmax 3.9 +/- 1.0, 2.8 +/- 0.9, and 1.9 +/- 0.7 micrograms.ml-1; AUC 16 +/- 5, 15 +/- 4, and 15 +/- 4 h.micrograms.ml-1; Cl 13 +/- 4, 14 +/- 4, and 14 +/- 3 L.h-1, respectively.
本文报道了42例呼吸道感染患者经3种给药途径使用氧氟沙星（Ofl）后的药代动力学特征。浓度-时间数据采用二室模型拟合静脉滴注（inf）和肌内注射（im）给药，一室模型拟合口服（po）给药。Ofl经静脉滴注、肌内注射和口服给药后的药代动力学参数分别为：β相半衰期或消除速率常数（T1/2β或T1/2K）6.0±1.3、5.0±1.0和5.0±0.7小时；中央室容积或分布容积（Vc或Vd）58±16、68±27和94±25升；血药浓度峰值（Cmax）3.9±1.0、2.8±0.9和1.9±0.7微克·毫升-1；药时曲线下面积（AUC）16±5、15±4和15±4小时·微克·毫升-1；清除率（Cl）13±4、14±4和14±3升·小时-1。
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