McGuirt W F, Greven K M, Keyes J W, Williams D W, Watson N E, Geisinger K R, Cappellari J O
Department of Otolaryngology, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC 27157-1034, USA.
Ann Otol Rhinol Laryngol. 1995 Apr;104(4 Pt 1):274-8. doi: 10.1177/000348949510400403.
Positron emission tomography (PET) is a relatively new radiologic imaging technique based on glucose analog uptake and metabolism in tumor tissue. In this study, PET was used in evaluating 38 patients with laryngeal cancer. Twenty-five patients were examined with PET prior to treatment to study the reliability of PET in identifying the primary tumor and assessing regional nodal status; 13 patients who had previously received irradiation with curative intent and who represented differential diagnostic problems were imaged to differentiate between irradiation effects and recurrent or residual cancer. Findings for both groups were compared to results of clinical evaluation and those of computed tomography (CT) and magnetic resonance imaging (MRI). The PET results were essentially identical to those of CT, MRI, and clinical evaluation in identifying metastatic lesions (82% correct), and were as reliable as CT and MRI for correctly identifying primary tumors (88%). Positron emission tomography was most helpful in differentiating recurrent tumor from postirradiation tissue sequelae. However, its lack of anatomic detail made PET less valuable for primary staging and therapeutic planning. It may enhance the diagnostic accuracy of CT and MRI where anatomic distortions occur or where diagnostic criteria for CT and MRI are ambiguous.
正电子发射断层扫描（PET）是一种相对较新的放射成像技术，基于肿瘤组织对葡萄糖类似物的摄取和代谢。在本研究中，PET被用于评估38例喉癌患者。25例患者在治疗前接受PET检查，以研究PET在识别原发肿瘤和评估区域淋巴结状态方面的可靠性；13例先前接受过根治性放疗且存在鉴别诊断问题的患者进行成像，以区分放疗效果与复发或残留癌。将两组患者的检查结果与临床评估结果以及计算机断层扫描（CT）和磁共振成像（MRI）的结果进行比较。PET在识别转移灶方面的结果与CT、MRI和临床评估的结果基本相同（正确识别率为82%），在正确识别原发肿瘤方面与CT和MRI一样可靠（正确识别率为88%）。正电子发射断层扫描在区分复发肿瘤与放疗后组织后遗症方面最有帮助。然而，其缺乏解剖细节使得PET在原发分期和治疗规划方面价值较低。在出现解剖结构扭曲或CT和MRI的诊断标准不明确的情况下，PET可能会提高CT和MRI的诊断准确性。
