Chen B X, Ding Y S, Chen L G
Affiliated Ganquan Hospital, Shanghai Railway Medical College.
Zhongguo Zhong Yao Za Zhi. 1994 Dec;19(12):726-7, 762.
In this study, castor seeds were processed by one of the traditional Chinese methods, LD50 was measured and tumor inhition tests in nude mice bearing human pulmonary carcinoma were conducted. The results showed that the processing method was able to lower the toxicity of castor seeds and maintain their antitumor effect, thus providing an experimental basis for oral administration of castor seeds in the therapy of pulmonary carcinoma.
本研究采用一种传统中药方法对蓖麻子进行炮制，测定其半数致死量（LD50），并在荷人肺癌裸鼠上进行抑瘤试验。结果表明，该炮制方法能够降低蓖麻子的毒性并保持其抗肿瘤作用，从而为蓖麻子口服治疗肺癌提供了实验依据。
