Gustafsson H, Franzén L, Henriksson R
Department of Oto-Rhino-Laryngology, Umeå University, Sweden.
Acta Oncol. 1995;34(2):193-7. doi: 10.3109/02841869509093955.
The acute and late effects of fractionated irradiation on rat parotid gland acinar cells were studied by light and electron microscopy. At 10 days after the last irradiation session (6 Gy or 9 Gy daily during five consecutive days) no effects were seen. At 180 days, minor loss of acini was detectable after a total dose of 30 Gy. After 45 Gy a massive acinar loss was seen at that time; the number of acini had diminished and minor duct-like structures and scattered amounts of fibrous stroma dominated the slides. The remaining acini were disorganized and usually larger compared with the control side and to non-irradiated animals. The acinar cells appeared larger than in the controls. The ducts were better preserved but the intercalated ducts often seemed to be larger than normal. We suggest that this phenomenon indicates a remaining capacity of the parotid gland to regenerate acinar cells even after high radiation doses.
通过光学显微镜和电子显微镜研究了分次照射对大鼠腮腺腺泡细胞的急性和晚期影响。在最后一次照射疗程后10天（连续5天每天照射6 Gy或9 Gy）未观察到影响。在180天时，总剂量30 Gy后可检测到腺泡轻微丢失。45 Gy后，此时可见大量腺泡丢失；腺泡数量减少，少量导管样结构和散在的纤维性基质在载玻片上占主导。与对照侧和未照射动物相比，剩余的腺泡排列紊乱且通常更大。腺泡细胞看起来比对照大。导管保存较好，但闰管似乎常比正常大。我们认为这种现象表明即使在高剂量辐射后，腮腺仍有再生腺泡细胞的能力。
