Cervellino J C, Araujo C E, Sánchez O, Miles H, Nishihama A
Oncology Unit, B. Houssay Hospital, Buenos Aires, Argentina.
Acta Oncol. 1995;34(2):257-9. doi: 10.3109/02841869509093965.
Thirty patients with advanced squamous cell carcinoma of the cervix were included in a phase II study with cisplatin (DDP) and ifosfamide (IF)/mesna. They received a median of 4 courses of chemotherapy and were all evaluable for response and toxicity. Each cycle consisted of 2,500 mg/m2 IF i.v. days 1-5; mesna 500 mg/m2 i.v. at hours 0 and 2, and 1,000 mg/m2 per os at hours 6 and 10, days 1-5; DDP 20 mg/m2 i.v., days 1-5. Cycles were repeated every 4 weeks. One patient obtained CR and 14 PR giving an overall response rate of 50%. Mean duration of response was 21 months. Anemia grade 3 developed in 7 patients, leukopenia grade 3 in 9 patients and grade 4 in one patient; thrombopenia grade 3 in 2; creatinine clearance grade 3 in one; CNS grade 3 in one and cystitis grade 3 in one patient. Overall median survival time was about 25+ months (3-63+); after a follow-up of 70 months, 11 patients (37%) are still alive with a median survival of 31+ months. IF plus DDP seems to be a good combination for treatment of advanced cervical cancer, with acceptable tolerance and response rate.
30例晚期宫颈鳞状细胞癌患者纳入了一项使用顺铂（DDP）和异环磷酰胺（IF）/美司钠的II期研究。他们接受了中位数为4个疗程的化疗，并且都可进行疗效和毒性评估。每个周期包括：第1 - 5天静脉注射2500mg/m²的IF；第1 - 5天，在第0小时和第2小时静脉注射500mg/m²的美司钠，在第6小时和第10小时口服1000mg/m²的美司钠；第1 - 5天静脉注射20mg/m²的DDP。每4周重复一个周期。1例患者获得完全缓解（CR），14例部分缓解（PR）；总缓解率为50%。平均缓解持续时间为21个月。7例患者出现3级贫血，9例患者出现3级白细胞减少，1例患者出现4级白细胞减少；2例患者出现3级血小板减少；1例患者出现3级肌酐清除率下降；1例患者出现3级中枢神经系统毒性；1例患者出现3级膀胱炎。总中位生存时间约为25 +个月（3 - 63 +）；随访70个月后，11例患者（37%）仍存活，中位生存时间为31 +个月。IF加DDP似乎是治疗晚期宫颈癌的一个良好组合，耐受性和缓解率均可接受。
