Fiorentini A, Berardi N, Maffei L
Istituto di Neurofisiologia C.N.R., Pisa, Italy.
Vis Neurosci. 1995 Jan-Feb;12(1):51-5. doi: 10.1017/s0952523800007306.
Recent electrophysiological and anatomical experiments in rats and cats have shown that treatment with the neurotrophic factor-nerve growth factor (NGF)-prevents the effects of monocular deprivation (MD) at the level of visual cortex and lateral geniculate nucleus. We tested whether NGF treatment was effective in preventing MD effects on visual behavior of monocularly deprived kittens. Behavioral visual acuity was measured in kittens that had been monocularly deprived and treated intraventricularly with NGF for 2 weeks during the critical postnatal period. The detrimental effects of MD on behavioral visual acuity were found to be largely prevented by NGF treatment.
近期在大鼠和猫身上进行的电生理及解剖学实验表明，用神经营养因子——神经生长因子（NGF）进行治疗，可在视皮层和外侧膝状体水平预防单眼剥夺（MD）的影响。我们测试了NGF治疗对预防MD对单眼剥夺小猫视觉行为的影响是否有效。在关键的出生后时期，对单眼剥夺并经脑室内注射NGF治疗2周的小猫测量其行为视敏度。结果发现，NGF治疗在很大程度上预防了MD对行为视敏度的有害影响。
