Hattori N, Ishihara T, Saiki Y, Moridera K, Hino M, Ikekubo K, Kurahachi H
Department of Endocrinology, Kobe City General Hospital.
Intern Med. 1994 Dec;33(12):813-6. doi: 10.2169/internalmedicine.33.813.
A patient with insulinoma had frequent hypoglycemic episodes with normal plasma insulin levels and insulin/glucose ratios. When immunoreactive insulin (IRI) concentrations in this patient were compared among plasma samples with the same C-peptide immunoreactivity (CPR) levels, the concentrations were significantly lower than in control patients with insulinoma and equal to or lower than those of normal subjects. In hepatic venous samples, CPR levels were significantly higher and the IRI/CPR molar ratios were lower than those in a control subject. These results may indicate that normoinsulinemia in this patient could be explained by increased hepatic extraction of insulin.
一名胰岛素瘤患者频繁出现低血糖发作，但其血浆胰岛素水平和胰岛素/葡萄糖比值正常。当在具有相同C肽免疫反应性（CPR）水平的血浆样本中比较该患者的免疫反应性胰岛素（IRI）浓度时，其浓度显著低于胰岛素瘤对照患者，且等于或低于正常受试者。在肝静脉样本中，CPR水平显著更高，IRI/CPR摩尔比低于对照受试者。这些结果可能表明，该患者的正常胰岛素血症可通过肝脏对胰岛素摄取增加来解释。
