Boffetta P, Merletti F, Magnani C, Terracini B
Unit of Analytical Epidemiology, International Agency for Research on Cancer, Lyon, France.
Eur J Cancer B Oral Oncol. 1994 Nov;30B(6):369-73. doi: 10.1016/0964-1955(94)90013-2.
Cases of oral cavity and oropharynx cancer diagnosed among the residents of Torino, Italy, between 1982 and 1984 (n = 143) were followed up to June 1990. During this period, 97 subjects (67.8%) died, 69 from oral or oropharyngeal cancer. 10 more cases died from causes possibly related to oral cancer. The overall relative 5-year survival rate was 37.2%. Men experienced a worse survival than women. No difference was shown according to age, education or occupation. Patients with smooth lesions had a poorer prognosis than those with fissured or granular lesions; no association between survival and colour, elevation, induration or bleeding from the lesion was found. Extension of the tumour and nodal involvement were strong and independent predictors of survival, but no difference was found between T1 and T2 lesions. Patients who reported a 2-3-month interval between onset of symptoms and diagnosis experienced a better survival than those with shorter or longer interval. Oropharynx cases had a better prognosis than cancers of the oral cavity.
对1982年至1984年间在意大利都灵确诊的143例口腔和口咽癌患者进行随访，直至1990年6月。在此期间，97名受试者（67.8%）死亡，其中69人死于口腔或口咽癌。另有10例死于可能与口腔癌相关的原因。总体5年相对生存率为37.2%。男性的生存率低于女性。在年龄、教育程度或职业方面未显示出差异。病变光滑的患者预后比有裂隙或颗粒状病变的患者差；未发现生存率与病变颜色、隆起、硬结或出血之间存在关联。肿瘤的扩展和淋巴结受累是生存的强有力且独立的预测因素，但T1和T2病变之间未发现差异。报告症状出现与诊断之间间隔为2至3个月的患者生存率高于间隔较短或较长的患者。口咽癌病例的预后优于口腔癌。
