Combes T, Beguin A M, Coulomb Y, Barouti H, Costa P
Institution Nationale des Invalides, Paris.
Prog Urol. 1995 Feb;5(1):49-57.
To study the action of an alpha blocker, Moxisylyte hydrochloride, during an intravenous test on the course of urethral pressure in women with urethral instability associated with urethral hypertonia.
The population consisted of 20 women with a mean age of 38 years, presenting with a clinical disorder of micturition (urinary incontinence: 15 cases, urgency: 17 cases, frequency, 17 cases) present for an average of 4 years and associated with resting urethral pressure variations ranging from 22 to 88 cm H2O (mean: 44.8 cm H2O) and static urethral pressures ranging 72 to 150 cm H2O (mean: 102.5 cm H2O). An urodynamic assessment was performed before and after intravenous injection of Moxisylyte hydrochloride at the dose of 0.5 mg/kg.
Moxisylyte hydrochloride induced a significant reduction of urethral pressure variations, ranging from 8 to 42 cm H2O (mean: 21.9 cm H2O) and static urethral pressures, ranging from 47 to 102 cm H2O (mean: 68.8 cm H2O). Treatment was well tolerated in every case.
These preliminary results need to be completed by a randomized placebo-controlled study to confirm a statistically significant effect of Moxisylyte hydrochloride on urethral pressure stability in women presenting with urethral instability.
研究α受体阻滞剂盐酸莫西赛利在静脉注射试验中对伴有尿道高压的尿道不稳定女性尿道压力变化过程的作用。
研究对象为20名平均年龄38岁的女性，她们存在排尿临床障碍（尿失禁：15例，尿急：17例，尿频：17例），平均病程4年，静息尿道压力变化范围为22至88厘米水柱（平均：44.8厘米水柱），静态尿道压力范围为72至150厘米水柱（平均：102.5厘米水柱）。在静脉注射0.5毫克/千克剂量的盐酸莫西赛利前后进行了尿动力学评估。
盐酸莫西赛利使尿道压力变化显著降低，范围从8至42厘米水柱（平均：21.9厘米水柱），静态尿道压力范围从47至102厘米水柱（平均：68.8厘米水柱）。所有病例对治疗耐受性良好。
这些初步结果需要通过随机安慰剂对照研究来完善，以证实盐酸莫西赛利对伴有尿道不稳定的女性尿道压力稳定性具有统计学上的显著效果。
