Lyon M E, Bremner D, Laha T, Malik S, Henderson P J, Kenny M A
Department of Laboratory Medicine, School of Medicine, University of Washington, USA.
Clin Biochem. 1995 Feb;28(1):79-84. doi: 10.1016/0009-9120(94)00062-z.
To determine whether heparin anticoagulants used for analysis of whole blood ionized calcium would influence the measurement of ionized magnesium.
The effects of zinc heparin, lithium heparin, and electrolyte-balanced heparin on the simultaneous measurement of ionized magnesium and ionized calcium in serum were determined using ion selective electrodes.
Time-dependent biases in ionized magnesium and calcium concentrations were apparent with zinc heparin but not with lithium or electrolyte-balanced heparin. Ionized magnesium and calcium concentrations were more significantly influenced by volume-dependent changes in zinc heparin potency than with lithium or electrolyte-balanced heparin.
Zinc heparin produces a significant positive bias in the simultaneous determination of ionized magnesium and ionized calcium concentrations.
确定用于全血离子钙分析的肝素抗凝剂是否会影响离子镁的测量。
使用离子选择性电极测定硫酸锌肝素、肝素锂和电解质平衡肝素对血清中离子镁和离子钙同时测量的影响。
硫酸锌肝素会使离子镁和钙浓度出现时间依赖性偏差，而肝素锂或电解质平衡肝素则不会。与肝素锂或电解质平衡肝素相比，硫酸锌肝素效价的体积依赖性变化对离子镁和钙浓度的影响更为显著。
在同时测定离子镁和离子钙浓度时，硫酸锌肝素会产生显著的正偏差。
