Cairns P A, Wilson D C, McClure B G, Halliday H L, McReid M
Neonatal Intensive Care Unit, Royal Maternity Hospital, Belfast, Northern Ireland.
Eur J Pediatr. 1995 Feb;154(2):145-7. doi: 10.1007/BF01991919.
A retrospective study was carried out comparing 61 very low birth weight infants (VLBW) with percutaneous central venous catheters with 92 infants managed with peripheral cannulae. Eighteen infants developed one or more episodes of catheter-associated bacteraemia. In 70% of cases the infection was successfully treated with the line in situ. Logistic regression analysis was performed to examine risk factors for bacteraemia. The duration of intravenous fluids and of intermittent positive pressure ventilation were both significant risks for infection (odds ratios and 95% confidence limits 4.4, 2.7-12.0 and 2.5, 1.0-6.1 respectively), but the presence of a silastic catheter was not an independent risk factor (odds ratio 0.6, 95% confidence limits 0.1-3.0).
Percutaneous central venous catheters provide a satisfactory means of delivering parenteral nutrition with minimal disturbance to ill VLBW infants.
进行了一项回顾性研究，比较了61例使用经皮中心静脉导管的极低出生体重儿（VLBW）与92例使用外周套管的婴儿。18例婴儿发生了一次或多次导管相关菌血症。在70%的病例中，感染通过保留导管成功治愈。进行了逻辑回归分析以检查菌血症的危险因素。静脉输液时间和间歇正压通气时间均为感染的显著危险因素（比值比及95%置信区间分别为4.4，2.7 - 12.0和2.5，1.0 - 6.1），但硅橡胶导管的存在并非独立危险因素（比值比0.6，95%置信区间0.1 - 3.0）。
经皮中心静脉导管为患病的极低出生体重儿提供了一种令人满意的肠外营养输注方式，对患儿干扰最小。
