Jennum P, Schultz-Larsen K, Davidsen M, Christensen N J
Department of Internal Medicine C, Glostrup Hospital, University of Copenhagen, Denmark.
Int J Epidemiol. 1994 Dec;23(6):1159-64. doi: 10.1093/ije/23.6.1159.
A number of studies have demonstrated an association between habitual snoring and cardiovascular morbidity and mortality. Control for the influence of potential confounders has been inadequate. To clarify the issue we examined the association between snoring and future risk of ischaemic heart disease (IHD) and stroke while controlling for the potential influence of major cardio- and cerebrovascular risk factors.
In all, 804 70 year old males and females were classified according to snoring habits. Alcohol and tobacco consumption, blood pressure, body mass index, social group, plasma lipids (triglycerides, cholesterol, high density lipoprotein), fasting blood glucose, plasma epinephrine and norepinephrine were determined at baseline.
Over a 6-year period (1984-1990) 88 suffered an IHD episode, 60 had a stroke and 180 died. A slightly higher stroke incidence was found among snorers (relative risk [RR] = 1.8; (95% confidence interval: 1.1-3.6). When adjustments were made for the above confounders, no associations could be found between snoring and IHD, stroke or all-cause mortality.
In a 70 year old population, snoring is not associated with an increased risk of IHD, stroke or all-cause mortality.
多项研究表明习惯性打鼾与心血管疾病的发病率及死亡率之间存在关联。对潜在混杂因素影响的控制并不充分。为阐明这一问题,我们在控制主要心脑血管危险因素潜在影响的同时,研究了打鼾与缺血性心脏病(IHD)及中风未来风险之间的关联。
总共804名70岁的男性和女性根据打鼾习惯进行分类。在基线时测定饮酒量、吸烟量、血压、体重指数、社会阶层、血脂(甘油三酯、胆固醇、高密度脂蛋白)、空腹血糖、血浆肾上腺素和去甲肾上腺素。
在6年期间(1984 - 1990年),88人发生IHD发作,60人中风,180人死亡。打鼾者中中风发病率略高(相对风险[RR] = 1.8;(95%置信区间:1.1 - 3.6)。在对上述混杂因素进行调整后,未发现打鼾与IHD、中风或全因死亡率之间存在关联。
在70岁人群中,打鼾与IHD、中风或全因死亡率风险增加无关。