Koskenvuo M, Kaprio J, Telakivi T, Partinen M, Heikkilä K, Sarna S
Br Med J (Clin Res Ed). 1987 Jan 3;294(6563):16-9. doi: 10.1136/bmj.294.6563.16.
The association of snoring with ischaemic heart disease and stroke was studied prospectively in 4388 men aged 40-69. The men were asked, in a questionnaire sent to them, whether they snored habitually, frequently, occasionally, or never. Hospital records and death certificates were checked for the next three years to establish how many of the men developed ischaemic heart disease or stroke: the numbers were 149 and 42, respectively. Three categories of snoring were used for analysis: habitual and frequent snorers (n = 1294), occasional snorers (n = 2614), and non-snorers (n = 480). The age adjusted relative risk of ischaemic heart disease between habitual plus frequent snorers and non-snorers was 1.91 (p less than 0.01) and for ischaemic heart disease or stroke, or both, 2.38 (p less than 0.001). There were no cases of stroke among the non-snorers. Adjustment for age, body mass index, history of hypertension, smoking, and alcohol use did not significantly decrease the relative risks, which were 1.71 (p greater than 0.05) for ischaemic heart disease and 2.08 (p less than 0.01) for ischaemic heart disease and stroke combined. At the beginning of follow up in 1981, 462 men reported a history of angina pectoris or myocardial infarction. For them the relative risk of ischaemic heart disease between habitual plus frequent snorers and non-snorers was 1.30 (NS); for men without previous ischaemic heart disease 2.72 (p less than 0.05). Snoring seems to be a potential determinant of risk of ischaemic heart disease and stroke.
对4388名年龄在40至69岁之间的男性进行了前瞻性研究,以探讨打鼾与缺血性心脏病及中风之间的关联。通过向这些男性发送问卷调查,询问他们是习惯性打鼾、经常打鼾、偶尔打鼾还是从不打鼾。在接下来的三年里,查阅医院记录和死亡证明,以确定有多少男性患上了缺血性心脏病或中风,患病人数分别为149人和42人。分析时将打鼾分为三类:习惯性和经常打鼾者(n = 1294)、偶尔打鼾者(n = 2614)和不打鼾者(n = 480)。习惯性加经常打鼾者与不打鼾者相比,缺血性心脏病的年龄调整相对风险为1.91(p < 0.01),缺血性心脏病或中风或两者兼有的年龄调整相对风险为2.38(p < 0.001)。不打鼾者中没有中风病例。对年龄、体重指数、高血压病史、吸烟和饮酒情况进行调整后,相对风险没有显著降低,缺血性心脏病的相对风险为1.71(p > 0.05),缺血性心脏病和中风合并的相对风险为2.08(p < 0.01)。在1981年随访开始时,有462名男性报告有心绞痛或心肌梗死病史。对他们来说,习惯性加经常打鼾者与不打鼾者相比,缺血性心脏病的相对风险为1.30(无统计学意义);对于既往无缺血性心脏病的男性,相对风险为2.72(p < 0.05)。打鼾似乎是缺血性心脏病和中风风险的一个潜在决定因素。