Bettocchi C, Coker C B, Deacon J, Parkinson C, Pryor J P
Institute of Urology, St. Peter's Hospital, London, United Kingdom.
J Androl. 1994 Nov-Dec;15 Suppl:14S-16S.
A group of 2,739 infertile men whose testes were biopsied during the investigation of infertility in the period from January 1955 to December 1992 have been reviewed. Unilateral intratubular germ cell neoplasia was seen in the testicular biopsies of 16 patients and was always associated with testicular atrophy (Johnsen score lower than 4). Germ cell tumors of the testis occurred in 50% of untreated patients within 6 years and the longest period of tumor-free follow-up was 10 years. A retrospective study was performed to evaluate the incidence of tumors in a subset of 1,639 infertile men biopsied between 1955 and 1982. Three of the patients, without intratubular germ cell neoplasia on the biopsy, were found to have developed a germ cell tumor. The incidence and management of intratubular germ cell neoplasia in infertile men is discussed.
对1955年1月至1992年12月期间因不育症接受检查时进行睾丸活检的2739名不育男性进行了回顾性研究。16例患者的睾丸活检中发现单侧睾丸内生殖细胞瘤，且均伴有睾丸萎缩（约翰森评分低于4分）。50%未治疗的患者在6年内发生睾丸生殖细胞肿瘤，无瘤随访最长时间为10年。对1955年至1982年间接受活检的1639名不育男性中的一部分进行了回顾性研究，以评估肿瘤的发生率。活检时无睾丸内生殖细胞瘤的3例患者被发现发生了生殖细胞肿瘤。本文讨论了不育男性中睾丸内生殖细胞瘤的发生率及处理。
