颗粒淋巴细胞增殖性疾病
Lymphoproliferative disease of granular lymphocytes.
作者信息
Kugelman L C, Smith B R, Buckley P, Katz M E, Edelson R L
机构信息
Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut, USA.
出版信息
J Am Acad Dermatol. 1995 May;32(5 Pt 2):829-33. doi: 10.1016/0190-9622(95)91541-9.
We report a case of lymphoproliferative disease of granular lymphocytes that was associated with cutaneous manifestations. Marker studies of skin and blood in this patient revealed that the circulating and infiltrating cells were negative for CD3 and T-cell antigen receptor but were positive for CD16, CD56, and CD57, suggesting natural killer cell origin. The patient had a rapidly progressive course and died within 1 month of presentation.
我们报告一例伴有皮肤表现的颗粒淋巴细胞增殖性疾病。对该患者皮肤和血液的标志物研究显示，循环细胞和浸润细胞CD3及T细胞抗原受体呈阴性，但CD16、CD56和CD57呈阳性，提示为自然杀伤细胞来源。该患者病程进展迅速，就诊后1个月内死亡。
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