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儿童和青年血清总胆固醇、高密度脂蛋白胆固醇及舒张压的聚类分析和六年聚类追踪:芬兰青年人心血管风险研究

Clustering and six year cluster-tracking of serum total cholesterol, HDL-cholesterol and diastolic blood pressure in children and young adults. The Cardiovascular Risk in Young Finns Study.

作者信息

Raitakari O T, Porkka K V, Räsänen L, Rönnemaa T, Viikari J S

机构信息

Cardiorespiratory Research Unit, University of Turku, Finland.

出版信息

J Clin Epidemiol. 1994 Oct;47(10):1085-93. doi: 10.1016/0895-4356(94)90094-9.

Abstract

Clustering and tracking of serum total cholesterol, high-density lipoprotein cholesterol (HDL-C) and diastolic blood pressure were studied in children and young adults. "High-risk" individuals were defined as those having these risk factors at the age and sex specific upper tertile (lowest tertile for HDL-C). Among older boys risk factors occurred at adverse levels more often than expected by chance. Cluster-tracking was assessed as the probability of remaining in the extreme tertiles during follow-up. Approximately 25% of subjects initially at "risk" remained there for 6 years. Subjects who became high-risk individuals during the follow-up expressed greater increase in obesity indices, started to consume more saturated fat and cholesterol and became physically active less often compared to those subjects who were initially at risk, but no longer at the follow-up.

摘要

对儿童和青年的血清总胆固醇、高密度脂蛋白胆固醇(HDL-C)及舒张压进行了聚类和追踪研究。“高危”个体被定义为在按年龄和性别划分的上三分位数(HDL-C为下三分位数)具有这些危险因素的个体。在年龄较大的男孩中,危险因素出现在不良水平的频率高于偶然预期。聚类追踪被评估为随访期间留在极端三分位数的概率。最初处于“高危”状态的受试者中约25%在6年内一直处于该状态。与那些最初处于高危状态但随访时不再高危的受试者相比,随访期间成为高危个体的受试者肥胖指数增加更大,开始摄入更多饱和脂肪和胆固醇,且身体活动频率更低。

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