带血管蒂髂骨移植修复下颌骨缺损的实验研究
Experimental reconstruction of mandibular defects with vascularized iliac bone grafts.
作者信息
Shirota T, Schmelzeisen R, Ohno K, Michi K I
机构信息
First Department of Oral and Maxillofacial Surgery, Showa University, Tokyo, Japan.
出版信息
J Oral Maxillofac Surg. 1995 May;53(5):566-71. doi: 10.1016/0278-2391(95)90070-5.
PURPOSE
The study evaluated the processes of incorporation and bone remodeling after microsurgical transplantation of iliac crest grafts for mandibular defect reconstruction.
MATERIALS AND METHODS
A defect in the mandibular angle measuring 2 x 4 x 1 cm was reconstructed in six Göttingen minipigs with a microvascularized iliac bone graft based on the circumflex artery. The animals were killed at 14, 28, and 56 days after transplantation and the healing process was histologically examined.
RESULTS
Although a constant vascular supply to the graft was restored by the microvascular reanastomosis, necrosis occurred in the major part of the bone marrow. New bone formation from the graft was markedly delayed compared with that from the mandible. Some osteocytes and marrow survived after grafting, but the volume of iliac bone tended to decrease gradually over time. In the 56-day specimens, the border between the graft and the mandible was not clear.
CONCLUSION
These findings indicate that survival of the vascularized iliac bone graft in the minipig is not complete.
目的
本研究评估了用于下颌骨缺损重建的髂嵴移植骨显微外科移植后的整合过程和骨重塑情况。
材料与方法
在6只哥廷根小型猪中，利用旋髂深动脉构建带血管蒂的髂骨移植骨，修复下颌角处大小为2×4×1厘米的缺损。在移植后14天、28天和56天处死动物，并对愈合过程进行组织学检查。
结果
尽管通过微血管再吻合恢复了移植骨持续的血供，但大部分骨髓发生了坏死。与下颌骨相比，移植骨的新骨形成明显延迟。移植后一些骨细胞和骨髓存活下来，但髂骨体积随时间逐渐减小。在56天的标本中，移植骨与下颌骨之间的边界不清晰。
结论
这些发现表明小型猪中带血管蒂的髂骨移植骨的存活并不完全。
Zotero 插件