1例伴有t(X;6)(p11.21;q23)的急性巨核细胞白血病，其X染色体断点位于一个450kb的区域内，该区域在两类实体瘤中也发生了破坏。
A case of acute megakaryoblastic leukaemia with t(X;6)(p11.21;q23) having an X chromosome breakpoint within a 450-Kb region which is also disrupted in two classes of solid tumours.
作者信息
Reeves B R, Knight J C, Renwick P J, Jani K, Kempski H
机构信息
Haematology and Oncology Unit, Institute of Child Health, London, UK.
出版信息
Leukemia. 1995 Apr;9(4):723-5.
PMID:7723409
Abstract
Karyotype analysis of a case of acute megakaryoblastic leukaemia revealed an X;6 translocation as the sole abnormality. Using fluorescence in situ hybridisation on leukaemic metaphases we demonstrated that the breakpoint on the X-chromosome occurred at p11.21, within a region spanned by a YAC probe which has also been found to be disrupted in synovial sarcomas and some papillary renal cell carcinomas.
摘要
对一例急性巨核细胞白血病病例进行核型分析，结果显示唯一的异常是X;6易位。我们利用白血病中期相的荧光原位杂交技术证实，X染色体上的断点位于p11.21，处于一个YAC探针所覆盖的区域内，该区域在滑膜肉瘤和一些乳头状肾细胞癌中也发现有断裂情况。
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