生物传感器：一种可行的监测技术？

Biosensors: a viable monitoring technology?

作者信息

Higson S P, Vadgama P M

机构信息

Department of Medicine, University of Manchester, Hope Hospital, UK.

出版信息

Med Biol Eng Comput. 1994 Nov;32(6):601-9. doi: 10.1007/BF02524233.

DOI:10.1007/BF02524233

PMID:7723416

Abstract

Biosensors for practical in vivo and in vitro applications are dependent on the effective integration of several biological and physical technologies. This review paper was stimulated by an IEE seminar. Some of the more recent advances aimed at taking techniques of fundamental and academic interest to various forms of practical reagentless biochemical analysis are highlighted, with associated clinical and commercial consequences. The paper describes some of the most recent developments in biosensor research, in particular those relating to material aspects of fabrication, including multilayer films for sensor applications, advances in ISFETs, conjugated polymers, new developments in quartz crystal based biosensors, as well as advances in amperometric enzyme electrodes and the application of devices for continuous monitoring.

摘要

用于实际体内和体外应用的生物传感器依赖于多种生物和物理技术的有效整合。这篇综述文章是受电气与电子工程师协会（IEEE）研讨会的启发而撰写的。文中重点介绍了一些旨在将具有基础和学术意义的技术应用于各种形式的无试剂生化分析的最新进展，以及相关的临床和商业影响。本文描述了生物传感器研究的一些最新进展，特别是与制造材料方面相关的进展，包括用于传感器应用的多层膜、离子敏感场效应晶体管（ISFET）的进展、共轭聚合物、基于石英晶体的生物传感器的新进展，以及电流型酶电极的进展和连续监测设备的应用。