Siemens AG, Medizinische Technik, Postfach 3260, D-8520, Erlangen.
Pharm Res. 1984 Nov;1(6):237-44. doi: 10.1023/A:1016385600306.
The prolonged controlled administration of drugs could benefit the treatment of several diseases. In some instances variable delivery rates are required, e.g. in the treatment of diabetes. Program controlled externally portable devices and fixed rate implantable pumps are rapidly gaining clinical acceptance. Widespread use of the considerably more complex implantable devices with variable rates for use in diabetes therapy is hampered by the persistant problem of the incompatibility of insulin with the pump at body conditions. The ideal devices, feed-back controlled implants, cannot be realized since long-term implantable sensors, e.g. of glucose, are not yet available. Prospective clinical trials are running for all applications to clarify the cost-benefit-risk relationships.
长期控制药物的给药可以有益于多种疾病的治疗。在某些情况下需要不同的输送速率，例如在糖尿病的治疗中。可编程的外部便携式装置和固定速率的植入式泵正在迅速获得临床认可。广泛使用用于糖尿病治疗的可变速率的、更复杂的植入式装置受到体内条件下胰岛素与泵不兼容这一持续存在的问题的阻碍。由于缺乏长期植入式传感器（例如葡萄糖传感器），反馈控制植入式装置这一理想设备无法实现。正在进行所有应用的前瞻性临床试验，以阐明成本效益风险关系。
