[生长抑素受体闪烁扫描术在甲状腺髓样癌、胃肠胰神经内分泌肿瘤及类癌肿瘤中的应用]
[Somatostatin receptor scintigraphy in medullary thyroid carcinomas, GEP and carcinoid tumors].
作者信息
Eising E G, Farahati J, Bier D, Knust E J, Reiners C
机构信息
Klinik und Poliklinik für Nuklearmedizin, Universität-GH-Essen, FRG.
出版信息
Nuklearmedizin. 1995 Feb;34(1):1-7.
For this study, 24 patients with medullary thyroid cancer (MTC) and 10 with carcinoid-/GEP-tumours underwent scintigraphy with 123I-Tyr3-octreotide or 111In-DTPA-D-Phe1-octreotide (Octreoscan) or 99mTc-V-DMSA. Calcitonin and CEA were elevated in MTC patients, the other had tumour lesions on CT. Octreoscan-scintigraphy was positive in 68% of all suspicious cases. On the other hand, 123I-Tyr3-octreotide showed only rarely positive results. 99mTc-V-DMSA-scans in MTC patients were positive in 23%. Liver metastases could be seen only with Octreoscan in the non-MTC-group. These results showed better sensitivity of 111In-labelled octreotide.
在本研究中，24例甲状腺髓样癌（MTC）患者和10例类癌/胃肠胰神经内分泌肿瘤患者接受了用123I-Tyr3-奥曲肽、111In-DTPA-D-Phe1-奥曲肽（奥曲肽扫描）或99mTc-V-DMSA进行的闪烁扫描。MTC患者的降钙素和癌胚抗原升高，其他患者在CT上有肿瘤病变。在所有可疑病例中，奥曲肽扫描闪烁成像的阳性率为68%。另一方面，123I-Tyr3-奥曲肽仅很少显示阳性结果。MTC患者中99mTc-V-DMSA扫描的阳性率为23%。在非MTC组中，仅奥曲肽扫描能发现肝转移。这些结果表明111In标记的奥曲肽具有更高的敏感性。
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