Kropp R, Göbel D
Internistisch-Pneumologische Gemeinschaftspraxis, Fulda.
Pneumologie. 1995 Feb;49(2):60-4.
Treatment with theophylline requires monitoring of dosage, preferably by determining the theophylline content in whole blood or serum, because theophylline pharmaco kinetics is most variable and therefore difficult to define, and because of possible interactions with other drugs. In medical practice, it is important and helpful to get the results of theophylline measurements quickly so that the dosage may be corrected directly whenever necessary. Two assays for rapid theophylline determination were compared with a standard method and with each other in respect of accuracy and practicability. Both methods a suitable for practical use.
使用茶碱进行治疗需要监测剂量，最好通过测定全血或血清中的茶碱含量来进行监测，这是因为茶碱的药代动力学变化最大，因此难以确定，还因为可能与其他药物发生相互作用。在医学实践中，快速获得茶碱测量结果非常重要且有帮助，这样在必要时可以直接调整剂量。将两种快速测定茶碱的方法与一种标准方法进行了准确性和实用性方面的比较，并且这两种方法也相互进行了比较。两种方法均适用于实际应用。
