血小板及其他非可兴奋细胞中的钙信号传导
Calcium signalling in platelets and other nonexcitable cells.
作者信息
Sargeant P, Sage S O
机构信息
Physiological Laboratory, Cambridge University, U.K.
出版信息
Pharmacol Ther. 1994;64(3):395-443. doi: 10.1016/0163-7258(94)90019-1.
PMID:7724656
Abstract
By virtue of their biological simplicity and widespread availability, platelets frequently have been used as a model system to study signal transduction. Such studies have revealed that changes in intracellular free calcium concentration are central to platelet functioning. The following article reviews current concepts of platelet structure and function, with particular emphasis on the mechanisms involved in platelet Ca2+ signalling.
摘要
由于血小板生物学特性简单且易于获取，它们常被用作研究信号转导的模型系统。此类研究表明，细胞内游离钙浓度的变化是血小板功能的核心。以下文章综述了血小板结构和功能的当前概念，尤其着重于血小板钙离子信号传导所涉及的机制。
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