Wiemann B, Starnes C O
Department of Pharmacology, Amgen, Inc., Thousand Oaks, CA 91320-1789, USA.
Pharmacol Ther. 1994;64(3):529-64. doi: 10.1016/0163-7258(94)90023-x.
As far back as the 1700s, it was recorded that certain infectious disease processes could exert a beneficial therapeutic effect upon malignancy. Most prominent among the numerous deliberate efforts made to take advantage of these observations was that of a pioneering New York surgeon, William B. Coley, active career 1891-1936. Using a bacterial vaccine to treat primarily inoperable sarcoma. Coley accomplished a cure rate of better than 10%. This review examines the history of these efforts and presents a discussion of their corresponding relevance to present day immunotherapy.
早在18世纪，就有记录表明某些传染病过程可能对恶性肿瘤产生有益的治疗效果。在众多利用这些观察结果的刻意努力中，最突出的是纽约一位开创性的外科医生威廉·B·科利（William B. Coley），他在1891年至1936年期间活跃于职业生涯。他主要使用细菌疫苗治疗无法手术的肉瘤，治愈率超过10%。这篇综述回顾了这些努力的历史，并讨论了它们与当今免疫疗法的相应相关性。
