Shaham Y, Kelsey J E, Stewart J
Department of Psychology, Concordia University, Montreal, Quebec, Canada.
Psychopharmacology (Berl). 1995 Jan;117(1):102-9. doi: 10.1007/BF02245104.
The role of associative factors in the effect of 15 min/day of restraint stress on morphine-induced behavioral sensitization was examined. Male rats were initially given seven systemic (10 mg/kg, IP) or intraventral tegmental area (VTA, 5 micrograms/side) [corrected] injections of morphine, and were exposed to restraint, either just prior to drug injection (Paired-Stress) or 24 h after injection (Unpaired-Stress), or to no restraint (Control). In subsequent tests for behavioral sensitization to low doses of morphine (0.75 or 3.0 mg/kg, IP), animals in the Paired-Stress condition were more active than animals in the Unpaired-Stress or Control conditions. These results indicate that temporal and possibly associative factors may contribute to stress-induced changes in sensitization to the behavioral activating effects of opioids.
研究了联想因素在每天15分钟束缚应激对吗啡诱导的行为敏化作用中的作用。雄性大鼠最初接受七次全身（10毫克/千克，腹腔注射）或腹侧被盖区（VTA，5微克/侧）[校正后]注射吗啡，并在药物注射前（配对应激）或注射后24小时（非配对应激）暴露于束缚状态，或不进行束缚（对照）。在随后对低剂量吗啡（0.75或3.0毫克/千克，腹腔注射）行为敏化的测试中，配对应激条件下的动物比非配对应激或对照条件下的动物更活跃。这些结果表明，时间因素以及可能的联想因素可能导致应激引起的对阿片类药物行为激活作用敏化的变化。
