Gueris J, Ferriere C
Pathol Biol (Paris). 1975 Dec;23(10):821-6.
The heterogeneity in the plasma of peptide hormones has been known for some time. The demonstration of various fragments of circulating parathormone was undertaken using two antisera, which permitted the authors to study: -- the plasma half-life of parathormone; -- the variations in parathormone levels during dynamic tests; -- the limits between normal and pathological levels. It was thus demonstrated that the antisera recognised, in one case, the terminal carboxyl fragment, in the other case, the terminal amino fragment.
肽类激素血浆中的异质性已为人所知有一段时间了。使用两种抗血清对循环甲状旁腺激素的各种片段进行了鉴定,这使作者能够研究:——甲状旁腺激素的血浆半衰期;——动态试验期间甲状旁腺激素水平的变化;——正常水平与病理水平之间的界限。结果表明,一种抗血清识别末端羧基片段,另一种抗血清识别末端氨基片段。