Immunopathology of experimental Jembrana disease in Bali cattle.

Sequential immunohistochemical studies of the lymphoreticular responses of Bali cattle (Bos javanicus syn. Bos sondaicus) after inoculation with the Jembrana disease virus were carried out using the peroxidase-antiperoxidase test for immunoglobulin containing cell assessment and the indirect immunoperoxidase test for lymphocyte subset assessment. The prevalence of immunoglobulin G-containing cells declined during the acute phase of the disease but became significantly elevated during convalescence. This trend was consistent with serological responses previously observed using an enzyme linked immunosorbent assay. Temporary immunosuppression appeared to occur during the acute phase of the disease as indicated by a decrease in the immunoglobulin G-containing cells in the lymphoid organs and an observed decrease in the BoCD4/BoCD8 lymphocyte ratio in lymph node follicles.