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Identification of an amino acid substitution involved in the reduction of sensitivity of HIV-1 to an inhibitor of viral proteinase.

作者信息

Turriziani O, Antonelli G, Jacobsen H, Mous J, Riva E, Pistello M, Dianzani F

机构信息

Institute of Virology, University La Sapienza, Rome, Italy.

出版信息

Acta Virol. 1994 Oct;38(5):297-8.

PMID:7726006
Abstract

Clones derived from HIV variants previously characterized as resistant to Ro31-8959, an inhibitor of viral proteinase (PR), were sequenced. Substitution of glycine by valine at position 48 of the PR protein was found. None of the 20 clones derived from wild type HTLV-IIIB contain this mutation. Since such a position is located in a conserved region of PR, it is possible that the substitution can affect the interaction of the enzyme with the inhibitor.

摘要

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