Jones S A, Adamson S L, Bishai I, Engelberts D, Norton J L, Coceani F
Division of Perinatology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ont., Canada.
Biol Neonate. 1994;66(6):339-51. doi: 10.1159/000244127.
During the perinatal period, prostaglandin (PG) E2 levels show parallel changes in cerebrospinal fluid (CSF) and blood which may be important for the adaptation of the fetus to extrauterine life. It is not known, however, whether PGE2 in the CSF originates from a local or a peripheral source. Experiments were carried out in term fetal and newborn sheep chronically instrumented with a cannula inside the third ventricle and vascular lines. Indomethacin was given intracerebroventricularly (i.c.v.) (50 or 100 micrograms at hourly intervals), alone or in combination with intravenous (i.v.) PGE2 (1 or 1.5 micrograms/kg/min). In the fetus, i.c.v. indomethacin reduced PGE2 levels in both CSF and plasma. Conversely, no significant change was noted at either site when indomethacin was given i.c.v. to the newborn. At both ages, PGE2 increased in the CSF during i.v. infusion of the compound, but this elevation was proportionately smaller than in plasma. We conclude that, in the perinatal period, brain and peripheral circulation function as separate compartments with respect to PGE2, though there is passage of the compound across the blood-brain barrier. Results provide indirect evidence that perinatal brain produces PGE2 in measurable amounts.
在围产期，前列腺素（PG）E2水平在脑脊液（CSF）和血液中呈现平行变化，这可能对胎儿适应宫外生活很重要。然而，尚不清楚脑脊液中的PGE2是源自局部还是外周。在足月胎儿和新生绵羊中进行了实验，这些动物长期通过第三脑室内的插管和血管通路进行监测。脑室内（i.c.v.）给予吲哚美辛（每小时50或100微克），单独给药或与静脉内（i.v.）PGE2（1或1.5微克/千克/分钟）联合给药。在胎儿中，脑室内给予吲哚美辛可降低脑脊液和血浆中的PGE2水平。相反，给新生动物脑室内注射吲哚美辛时，在两个部位均未观察到显著变化。在两个年龄段，静脉输注该化合物期间脑脊液中的PGE2均升高，但这种升高幅度比血浆中的小。我们得出结论，在围产期，就PGE2而言，脑和外周循环是相互独立的隔室，尽管该化合物可通过血脑屏障。结果提供了间接证据，表明围产期脑可产生可测量量的PGE2。
