Zhang W W, Roth J A
Department of Thoracic and Cardiovascular Surgery, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
In Vivo. 1994 Nov-Dec;8(5):755-69.
Rapid advances in cancer gene therapy are driven by an explosive development of gene transfer technology and a strong demand for effective alternatives to unsatisfactory conventional cancer therapies. Discovery of the genetic basis of cancer has indicated that cancer is a disease of genes. Among a variety of approaches to gene therapy of cancer, anti-oncogene and tumor suppressor gene therapy of cancer are the two strategies that aim at correcting genetic disorders of cancer. The potential effectiveness of these approaches is promised by their precise targeting at the mechanisms of the disease. Successful examples of human lung cancer animal models by applying anti-K-ras retrovirus and recombinant p53 adenovirus are reviewed. Future development of these approaches towards clinical application is also discussed.
癌症基因治疗的快速进展是由基因转移技术的迅猛发展以及对不尽人意的传统癌症治疗方法的有效替代方案的强烈需求所推动的。癌症遗传基础的发现表明癌症是一种基因疾病。在多种癌症基因治疗方法中，癌症的抗癌基因和肿瘤抑制基因治疗是旨在纠正癌症基因紊乱的两种策略。这些方法的潜在有效性因其对疾病机制的精确靶向而得到保证。本文综述了应用抗K-ras逆转录病毒和重组p53腺病毒建立人肺癌动物模型的成功实例。还讨论了这些方法在临床应用方面的未来发展。
