Kitson R P, Brunson K W, Miller C A, Goldfarb R H
Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, PA 15213, USA.
In Vivo. 1994 Nov-Dec;8(5):803-6.
There is increasing evidence to suggest a link between the neuroendocrine system and the immune system. Since it is well known that the immune response influences the establishment, progression or elimination of malignancy, we have examined the effects of adrenalectomy on B16 melanoma pulmonary tumor metastases and immune function in C57BL/6 mice to investigate the role of adrenal corticosteroids. Adrenalectomized mice were injected with 10(5) B16 melanoma cells on day 0. On day 9 the mice were sacrificed and the number of lung colonies counted. Adrenalectomized animals had a greater than 3 to 4-fold increase in the number of metastases as compared with sham operated animals. Steroid replacement therapy using dexamethasone delivered at 1 microgram/hr did not lead to any reduction in tumor metastases in adrenalectomized animals. These studies indicate that normal levels of adrenal steroids may influence the ability of tumor cells to colonize target organs and/or the ability of the immune system to mount an effective response.
越来越多的证据表明神经内分泌系统与免疫系统之间存在联系。由于众所周知免疫反应会影响恶性肿瘤的发生、发展或消除，我们研究了肾上腺切除术对C57BL/6小鼠B16黑色素瘤肺肿瘤转移和免疫功能的影响，以探讨肾上腺皮质类固醇的作用。在第0天给肾上腺切除的小鼠注射10(5)个B16黑色素瘤细胞。在第9天处死小鼠并计数肺集落的数量。与假手术动物相比，肾上腺切除的动物转移灶数量增加了3至4倍以上。以1微克/小时的剂量给予地塞米松进行类固醇替代疗法，并未导致肾上腺切除动物的肿瘤转移减少。这些研究表明，正常水平的肾上腺类固醇可能会影响肿瘤细胞在靶器官定植的能力和/或免疫系统产生有效反应的能力。
