Urdl W, Desoye G
Klinische Abteilung für gynäkologische, Universitätsklinik Graz, Osterreich.
Gynakol Geburtshilfliche Rundsch. 1995;35(1):12-5. doi: 10.1159/000272463.
Growth factors (human growth hormone, HGH; insulin-like growth factor I, IGF-I) and insulin were evaluated concerning their pathogenetic significance in patients with polycystic ovary syndrome (PCOS).
Twenty-eight women with signs of PCOS were examined; 24 women without signs of PCOS served as controls.
Women with PCOS showed significantly increased androgen, IGF-I, insulin and glucose levels, higher glucose concentrations in the oral glucose tolerance test and a higher body mass index. The concentration of HGH, the HGH/IGF-I ratio and the number of insulin receptors on red blood cells were significantly decreased in women with PCOS. The insulin receptor affinity, the maximum binding and the insulin-receptor complex were increased in PCOS patients.
A decreased number of insulin receptors, a disturbed insulin receptor binding, the resulting hyperinsulinemia as well as high levels of IGF-I are to be considered as important factors in the pathogenesis of PCOS.
评估生长因子（人类生长激素，HGH；胰岛素样生长因子I，IGF-I）和胰岛素在多囊卵巢综合征（PCOS）患者发病机制中的意义。
对28名有PCOS体征的女性进行检查；24名无PCOS体征的女性作为对照。
PCOS女性的雄激素、IGF-I、胰岛素和葡萄糖水平显著升高，口服葡萄糖耐量试验中的葡萄糖浓度更高，体重指数更高。PCOS女性的HGH浓度、HGH/IGF-I比值和红细胞上胰岛素受体的数量显著降低。PCOS患者的胰岛素受体亲和力、最大结合力和胰岛素-受体复合物增加。
胰岛素受体数量减少、胰岛素受体结合紊乱、由此导致的高胰岛素血症以及高水平的IGF-I被认为是PCOS发病机制中的重要因素。
