Schuler U, Ehninger G
Department of Internal Medicine I, Technical University of Dresden, Germany.
Bone Marrow Transplant. 1994;14 Suppl 4:S61-5.
Bacterial and fungal infections continue to be a major threat to bone marrow transplant recipients. While standardized approaches to empiric therapy with early inclusion of antibiotics active against Gram-positive organisms and against fungi may have improved the outcome of these patients during the past decade, other developments (e.g. increasing number of patients in older age groups, unrelated donors, mismatch transplants) may even have increased the problem. Current approaches to the prophylaxis and treatment of these infections are discussed. Concerning fungal infections especially the new azoles and new approaches of amphotericin B administration are of interest.
细菌和真菌感染仍然是骨髓移植受者面临的主要威胁。在过去十年中，早期纳入针对革兰氏阳性菌和真菌的抗生素进行经验性治疗的标准化方法可能改善了这些患者的治疗结果，但其他一些情况（例如老年患者、无关供体、不匹配移植患者数量的增加）甚至可能使问题更加严重。本文讨论了目前针对这些感染的预防和治疗方法。关于真菌感染，尤其是新型唑类药物和两性霉素B的新给药方法备受关注。
