Schuller E
INSERM U134, Hôpital de la Salpêtrière, Paris.
Transfus Clin Biol. 1995;2(1):57-66. doi: 10.1016/s1246-7820(05)80023-0.
Short term and long term beneficial effects of IgG administration have been studied in 4 groups of neuro-immunological diseases: Polymyositis, dermatomyositis and myasthenia. Peripheral neuropathies (myelinopathies), primarily in Guillain-Barré syndrome and in chronic inflammatory polyneuropathy. Children intractable Epilepsy. Multiple Sclerosis. Actual results are in favor of an objective and marked improvement (after 1 or 2 months) in the first 2 groups using intravenous IgG. In M.S. patients, the short term treatment of bouts (especially: optic neuritis) seems promising. Results of the only one long term (later than 10 years) trial are in favor of a significant slowing of the progression of M.S. comparatively to the predictive curve of disease.
已在4组神经免疫疾病中研究了静脉注射免疫球蛋白（IgG）的短期和长期有益效果：多发性肌炎、皮肌炎和重症肌无力。周围神经病（髓鞘病），主要是格林-巴利综合征和慢性炎性多神经病。儿童难治性癫痫。多发性硬化症。实际结果表明，在前两组中使用静脉注射IgG可在1或2个月后实现客观且显著的改善。在多发性硬化症患者中，对发作（尤其是视神经炎）的短期治疗似乎很有前景。唯一一项长期（超过10年）试验的结果表明，与疾病预测曲线相比，多发性硬化症的进展明显减缓。
