Watts R L, Mandir A S, Bakay R A
Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
Cell Transplant. 1995 Jan-Feb;4(1):27-38. doi: 10.1177/096368979500400106.
To examine the effects of autologous sural nerve and adrenal medullary tissue intrastriatal cografts upon voluntary motor performance in parkinsonism, a non-human primate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model was employed to quantitatively assess skilled hand movements. Motor performance was studied in normal, MPTP-induced parkinsonian, and then cografted states. Reaction and movement times were prolonged and variability increased in experimental and control animals in the parkinsonian state. Animals undergoing autologous cografts demonstrated improved motor performance whereas the control animal continued in a chronic, stable parkinsonian state. Intrastriatal cografts of autologous adrenal medullary tissue and sural nerve resulted in good to excellent chromaffin cell survival. The mechanism of the restoration of function in the cografted monkeys remains to be determined.
为研究自体腓肠神经和肾上腺髓质组织脑内纹状体移植对帕金森病患者自主运动能力的影响，采用非人灵长类1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）模型对熟练手部动作进行定量评估。研究了正常、MPTP诱导的帕金森病以及移植后的运动表现。在帕金森病状态下，实验动物和对照动物的反应时间和运动时间延长，变异性增加。接受自体移植的动物运动能力有所改善，而对照动物则持续处于慢性、稳定的帕金森病状态。自体肾上腺髓质组织和腓肠神经脑内纹状体移植导致嗜铬细胞存活良好至优秀。移植猴功能恢复的机制仍有待确定。
