Cheung L Y, Reese R S, Moody F G
Surgery. 1976 May;79(5):564-8.
The effects of intra-arterial infusion of E. coli endotoxin at 1.0 mg. per minute on the gastric total and mucosal blood flows, electrical potential difference, and ionic fluxes across the gastric mucosa were studied in an exteriorized, chambered preparation of canine fundic stomach. Gamma-labelled microsphere technique was used in addition to venous drainage and plasma aminopyrine clearance for the measurement of total and mucosal blood flow, respectively. In spite of normal systemic blood pressure throughout the experiment, E. coli endotoxin infusion caused a significant decrease in total gastric blood flow and in the fractional distribution of flow to the mucosae. There was no significant arteriovenous shunting of microspheres. Significant reduction in potential difference and hydrogen-ion back diffusion also was noted after endotoxin infusion, possibly as a consequence of reduced mucosal blood flow. The results indicate that significant gastric mucosal ischemia can occur and may represent a mechanism in the development of gastric erosions in endotoxemia, even in the absence of systemic hypotension.
在犬胃底部外置的、有腔室的制备模型中，研究了以每分钟1.0毫克的速度动脉内输注大肠杆菌内毒素对胃总血流量、黏膜血流量、电位差以及跨胃黏膜离子通量的影响。除了分别使用静脉引流和血浆氨基比林清除率来测量总血流量和黏膜血流量外，还采用了γ标记微球技术。尽管在整个实验过程中全身血压正常，但输注大肠杆菌内毒素导致胃总血流量以及流向黏膜的血流分数分布显著降低。微球没有明显的动静脉分流。内毒素输注后还观察到电位差和氢离子反向扩散显著降低，这可能是黏膜血流量减少的结果。结果表明，即使在没有全身性低血压的情况下，也可能发生显著的胃黏膜缺血，这可能是内毒素血症中胃糜烂发生发展的一种机制。
