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[术中放疗联合切除刮除术治疗胃癌的贡献与局限性]

[Contribution and limitations of peroperative radiotherapy combined with excision-curettage in the treatment of gastric cancers].

作者信息

Farthmann E H, Kirchner R, Salm R, Strasser C, Frommhold H, Nilles A

机构信息

Département de Chirurgie générale, Université Freiburg im Brisgau.

出版信息

Chirurgie. 1993;119(9):565-8.

PMID:7729206
Abstract

Macro- or microscopic residual tumor after surgery is the dominating prognostic factor in the treatment of gastric cancer. The majority of patients die of local recurrence and peritoneal spread. Therefore, in addition to gastrectomy and extended lymphadectomy (compartments 1 & 2) in some centers a adjuvant intraoperative radiotherapy is performed. Recent results of adjuvant intraoperative radiotherapy for gastric cancer revealed a lower local recurrence but there was no improvement in the survival rate for advanced tumor stages. These results are confirmed by our prospective study including 36 patients till now: in the group of 21 survivors there is no sign of a local recurrence. In 15 patients which died meanwhile there was only one case of local recurrence (median follow-up: 9 months, range 1-30 months). Peritoneal spread and liver metastasis were observed as the most frequent cause of death (tumor stage IIIB and IV only).

摘要

手术后的宏观或微观残留肿瘤是胃癌治疗中主要的预后因素。大多数患者死于局部复发和腹膜转移。因此,除了胃切除术和在一些中心进行的扩大淋巴结清扫术(第1和第2区)外,还进行了术中辅助放疗。胃癌术中辅助放疗的最新结果显示局部复发率较低,但晚期肿瘤阶段的生存率没有提高。我们目前纳入36例患者的前瞻性研究证实了这些结果:在21名存活者组中没有局部复发的迹象。在同时死亡的15例患者中,只有1例局部复发(中位随访时间:9个月,范围1 - 30个月)。腹膜转移和肝转移是观察到的最常见死亡原因(仅适用于IIIB期和IV期肿瘤)。

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